Listed as the third leading cause of death among 15-24 year olds, suicide is very common among college students. Spiritual health is not properly addressed with mental health and suicide even though past research have found that spirituality is important in helping mental health. Spiritual health leads to a sense of purpose and meaning which could mean a better mental health. The paper studies three major questions: (1) Does involvement in organized religion activities cause less thoughts of suicide? (2) Does spiritual well-being, specifically religious well-being and existential well-being, cause less thoughts of suicide? (3) Does the relationship between spiritual well-being and suicidality continue after a factor likely to change is controlled? After taking out invalid and incomplete questionnaires there was a total of 457 participants from lecture courses at University of Florida who were mostly female and ranged from 18 to 24 years of age. The scores were measured based on numerous scales in order. The Spiritual Well-Being Scale (SWBS) was used which included items that measured religious well-being (RWB) which consisted of references to God and existential well-being (EWB) which did not consist of references to God. There was 20 items with a 6-point scale ranging from 1 (strongly disagree) to 6 (strongly agree). Ten of the items were RWB and the other ten were EWB. Religiosity was determined by participation in church activities. Hopelessness was measured by the Beck Hopelessness Scale, with 20 items. A higher score meant a higher degree of hopelessness. Depression was measured by the Epidemiologic Studies Depression Scale, with 20 items. A higher score meant more depressive symptoms. Social Support was measured by the Personal Resource Questionnaire, with 25 items. Higher scores meant more social support. Suicidal thoughts were measured by the Adult Suicidal Ideation Questionnaire, with 25 items. Descriptive statistics were then calculated. Before analyzing major results correlation with the major research questions, evaluation of primary study variables, demographics: gender, age, and race and ethnicities were carried out. EWB, RWB, and SWB for participants with different races and ethnicities were compared. African Americans had higher levels of religious and total spiritual well-being. Religious well-being, existential well-being, total spiritual well-being, psychosocial variables, and suicidal ideation were then compared for relationships. The result was a higher religious, existential, and total spiritual well-being meant lower levels of hopelessness, depression, and suicidal ideation with high levels of social support. Suicidal ideation and psychosocial variables were then compared among 4 groups with involvement with organized religion. The higher level of participation meant lower levels of depression and hopelessness. A multiple linear regression model was then constructed to compared the multiple variables with religious and spiritual correlations of suicidal ideation. The study results show that higher levels of involvement meant better mental health and higher levels of religious and existential well-being had lower levels of thoughts of suicide. These results answered the first two major research questions being studied. Participating in an organized religion and religious well-being did not show to cause thoughts of suicide, after controlling demographic and psychosocial factors. Existential well-being was still strongly correlated with mental health and thoughts of suicide. Many participants in the study did not have great involvement with religious organizations but had high levels of spiritual well-being. Overall, the study found that a sense of purpose or meaning of life is important for individuals in decreasing distress and preventing suicide.