Microbes, such as bacteria, molds, yeasts, and viruses, in living
environment are often pathogenic and cause severe infections in human beings.
The treatment of infectious diseases is one of the most important and
challenging issues because of the increasing number of resistant microbial pathogens
1. Therefore, there is a tremendous need for developing or finding a new
effective antimicrobial agents from
natural and inorganic substances2.Silver ions (Ag+) and its compounds are
highly toxic to microorganisms exhibiting strong biocidal effects on many
species of bacteria but have a low toxicity towards animal cells. Therefore,
silver ions that have being antibacterial component are employed in formulation
of dental resin composites, bone cement, ion exchange fibers and coatings for
medical purposes 3,4. The coordinating ligands of the silver(I) complexes
play an important role as carrier for the silver(I) ion to the biological
system5,6. Antimicrobial nanoparticles, that primarily consist of metals,
metal oxides, and many biologically derived
materials, might be a promising antimicrobial agent to which pathogens
may not develop resistance7. Its antimicrobial activity is associated with
the characteristic structure of nanoparticles 8.The effective antimicrobial
properties of these materials are mainly due to their nano size providing them
unique chemical and physical properties such as increased surface to volume
ratio and high reactivity7. More recently, silver nanoparticles are started
to be commonly used in the antimicrobial field for taking care of virous types
of microbes such as fungi, virus, and bacteria9. The silver nanoparticales
(AgNPs) are very powerful tool that have many positive applications include in
vitro use, used as biosensor materials.
Furthermore, silver nanoparticles show to be a positive to enhance wound healing if AgNPs are used
correctly in the medical industry due to their antibacterial, antifungal, antiviral, anti inflammatory and
osteoinductive effect 10.
aims to synthesize and characterize a novel Ag(I) complex of 2-MBT and use the ligand 2-MBT as a
reducing agent to synthesize silver nanoparticle It highly predicted to become the useful tool
to fight against microbial infections in the near future.