defined as the histological development of regenerative nodules surrounded by
fibrous bands in response to chronic liver injury, leading to portal
hypertension and End Stage Liver Disease (ESLD) progressing to Cirrhosis and finally
leading to decompensated liver disease.”
Cirrhosis is one of the leading causes of death in
Asia as it ranks tenth most common cause of death in US, whereas worldwide, it
is the 12th most common cause. Medical treatments that may slow down the progression
of compensated cirrhosis to decompensated cirrhosis are under research phase.
Liver Transplantation is however the only option in a selected subgroup of
patients with ESLD and HCC.
Vitamin D is also known to have multiple
extraskeletal functions. The liver is the main organ involved in the synthesis
and metabolism of vitamin D after kidneys.
25-hydroxylation occurs inliver thereby converting it into active form.
There are various experimental studies have demonstrated an increase in vitamin
D deficiency prevalance and its insufficiency in patients with chronic liver
disease and cirrhosis. It is often seen that sometimes even in the absence of
cirrhosis, vitamin D deficiency may be detected in the majority of subjects.
However those subjects who had cirrhosis, vitamin D deficiency(